British anti-Lewisite (BAL; dimercaprol; 2,3-dimercaptopropanol) has been in use in the medical community for over 60 years. It is most commonly used as a. Dimercaprol is the drug of choice for treatment of acute arsenic, inorganic or elemental mercury, gold, and inorganic lead (in combination with EDTA) poisoning. The development of BAL must first start with its nemesis: Lewisite. Lewisite is a combination of acetylene and arsenic trichloride (figure 1) and has also been.
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British anti-Lewisite (dimercaprol): an amazing history.
It does, however, remove inorganic mercury from the kidneys; but is not useful in the treatment of alkylmercury or phenylmercury toxicity. Wilson’s disease is a genetic disorder in which copper builds up inside the liver and other tissues. Arsenic poisoning Dimercaprol Succimer.
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Human and Experimental Toxicology This page was last edited on 13 Novemberat Lorincz of the University of Michigan has no relevant financial relationships to disclose. Discover some of the most interesting and trending topics of Please try again later. Lweisite is more effective if its use is begun within two hours after ingestion of the toxic metal.
It was also considered effective in cases of intoxication with bismuth, copper, and nickel Deichmann and Gerarde Eagle and Magnuson found that 48 patients with severe or mild symptoms of arsenical encephalopathy were effectively treated with BAL Eagle and Magnuson There was a problem with your submission.
BAL is not generally recommended for use today because more efficient and safer chelators for oral or parenteral administration have been developed Andersen ; Briish et al ; Archer Experimental observations revealed that dimercaprol may be an effective neuroprotective agent.
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The Royal Society of Chemistry.
British anti-Lewisite Molecule of the Month – May
Automobile, a usually four-wheeled vehicle designed primarily for passenger transportation and commonly…. Dimercaprol compound is useful for the treatment of potentially life-threatening acute arsenic poisoning as well.
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Dimercaprol has been found to form stable chelates in vivo with many other metals including inorganic mercuryantimonybismuthcadmiumchromiumcobaltgoldand nickel. InPorter found a 7-fold increase in copper excretion in 2 pewisite with Wilson disease and some decrease in neurologic signs after treatment with BAL Porter Chronicle of a Twentieth Century Medical Triumph. International journal of immunopathology and pharmacology.
Goals and duration of treatment. Rev Environ Contam Toxicol Parenteral British anti-Lewisite can be successfully used in lead poisoning if oral therapy fails. Other agents have been developed since Brewer Dimercaprol also enhances the toxicity of selenium and telluriumso it is not to be used to remove these elements from the body.
Copper sulfate Ipecacuanha Syrup of ipecac. Our editors will review what you’ve submitted, and if it meets our criteria, we’ll add it to the article.
British anti-Lewisite :: Development
BAL s use as the primary treatment for Wilson disease was short-lived because Walshe, inshowed the value of the less toxic chelating agent, penicillamine Walshe Site license users, click the Site License Acces link on brtiish Homepage at an authorized computer.
Dimercaprol is a copper chelating agent that has been approved by the FDA to treat Wilson’s disease. In This Article Introduction.