Dofetilide (Tikosyn) Considerations for Use*. US/FDA Special Notes. The patient must be registered to receive this drug; the hospital and pharmacy must. Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Tikosyn (Dofetilide). (dofetilide) product monograph and refers you to more detailed information in read the patient package insert and reread it each time therapy is renewed in.

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Severe Tacrolimus prolongs the QTc interval. Dofetilide plasma concentrations are linearly related to drug dosage.

Before initiating sotalol, dofetilide should be withdrawn under careful monitoring for a minimum of plasma half-lives for dofetilide. Severe Coadministration of ivosidenib fofetilide dofetilide is contraindicated due to an increased risk of QT prolongation. Major Zafirlukast, a CYP 3A4 inhibitor, may increase plasma dofetilide concentrations with potential for dofetilide toxicity. If the QTc exceeds milliseconds or msec in patients with ventricular conduction abnormalities at any time, dofetilide therapy should be discontinued.

Moderate A clinically relevant increase in the plasma concentration of dofetilide may occur if given with letermovir; monitor patient closely for dofetilide-related adverse events.

Severe Concomitant use of ziprasidone and class III antiarrhythmics, such as dofetilide, is contraindicated by the manufacturer of ziprasidone due to the potential for additive QT prolongation and torsade de pointes TdP. Major Coadministration of lamotrigine and dofetilide is not recommended. Because of the potential forTdP, use of dofetilide with tacrolimus is contraindicated. TdP and ventricular tachycardia have been reported during post-marketing use of anagrelide.

Patients receiving other drugs which have the potential insetr QT prolongation, such as class III antiarrhythmics, have an increased risk of developing dofftilide during bepridil therapy.

Solifenacin has been associated dose-dependent prolongation of the QT interval. The concomitant use of dronedarone with other drugs that prolong the QTc may induce TdP and is contraindicated.

Excessive doses particularly in the overdose setting or IV administration of haloperidol may be pxckage with a insertt risk of QT prolongation. Because of the potential for TdP, use of dofetilide with telavancin is contraindicated Telithromycin: Because of the potential for TdP, use of vemurafenib with dofetilide is contraindicated.


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In vitro, dofetilide is a CYP3A4 substrate, although it has low affinity for this isoenzyme. Severe Coadministration of dofetilide and tafenoquine is contraindicated due to the potential for increased dofetilide concentrations and arrhythmias QT prolongation and torsade de pointes.

QT prolongation should be expected with the administration of arsenic trioxide. Severe Coadministration of dofetilide and azithromycin is contraindicated since there is an increased risk for QT prolongation and torsade de pointes TdP.

Because of the potential for QT prolongation and TdP, use of efavirenz with dofetilide is contraindicated. Severe The concomitant use of erythromycin and dofetilide is contraindicated.

The OBRA guidelines caution that antiarrhythmics can have serious adverse effects e. Dofetilide is a minor CYP3A4 substrate; however, because there is a linear relationship between dofetilide plasma concentration and QTc, concomitant administration of CYP3A4 inhibitors may increase the risk of arrhythmia torsade de pointes.

If a breast-feeding infant experiences an adverse effect related to a maternally ingested drug, healthcare providers are encouraged to report the adverse effect to the FDA. Fluconazole has been associated with QT prolongation and rare cases of TdP. Case reports indicate that QT prolongation and torsade de pointes TdP can occur during donepezil therapy.

Major Drugs that are actively secreted via cationic tubular secretion, such as triamterene, should be co-administered with caution with dofetilide since they could increase dofetilide plasma concentrations via potential competition for renal cationic secretion.

Tikosyn (dofetilide) dose, indications, adverse effects, interactions from

Severe The concurrent use of amiodarone and dofetilide is contraindicated. Everolimus is a weak CYP3A4 inhibitor. Because pimavanserin causes QT prolonging effects that may be additive to those of dofetilide, coadminisitration is contraindicated.

Clinicians should observe patients closely if St. Because of the potential for TdP, use of fluoxetine with dofetilide is contraindicated. We do not record any personal information entered above. Severe Telavancin has been associated with QT prolongation.

Severe Hypokalemia or hypomagnesemia may occur with administration of potassium-depleting drugs such as loop diuretics and thiazide diuretics, increasing the potential for dofetilide-induced torsade de packaage.


Dofetilide (Tikosyn) | Pharmacy

Dofetilide is classified by the FDA as a pregnancy risk category C drug. Because of the potential for TdP, use of dofetilide with leuprolide is contraindicated. QT prolongation has been reported with panobinostat therapy in patients with multiple myeloma in a clinical trial; use of panobinostat with other agents that prolong the QT interval is not recommended.

Patients with atrial fibrillation AF should be anticoagulated according to usual medical practice prior to electrical or pharmacological cardioversion.

Moderate Monitor for an increase in dofetilide-related adverse reactions, including QT prolongation, if coadministration inserf larotrectinib is necessary. There was no evidence of a negative inotropic effect related to dofetilide therapy in patients with atrial fibrillation.

QT prolongation and TdP have been observed during haloperidol treatment. John’s wort could decrease the efficacy of some medications metabolized by CYP3A4, such as dofetilide. Coadministration of conivaptan with dofetilide should be undertaken with extreme caution. Moderate Monitor for an increase in dofetilide-related adverse reactions, including QT prolongation, if coadministration with amlodipine is necessary.

Potassium levels should be within the normal range prior and during administration of dofetilide. Moderate Colesevelam may decrease the absorption of oral antiarrhythmics. Because buprenorphine has also been associated with QT prolongation and has a possible risk of torsade de pointes TdPcoadministration is contraindicated. The clinical significance of this interaction is unknown. Because of the potential for TdP, use of dofetilide with moxifloxacin is contraindicated.

Send the page ” ” to a friend, relative, colleague or yourself. There have been postmarketing reports of QT prolongation and TdP during treatment with sertraline and the manufacturer of sertraline recommends avoiding concurrent use with drugs known to prolong the QTc interval. Severe Because of the potential for torsades de pointes TdPconcurrent use of granisetron and dofetilide is contraindicated. Omeprazole, ranitidine, or antacids aluminum and magnesium hydroxides may be used as anti-ulcer therapy alternatives to cimetidine; these agents did not alter dofetilide pharmacokinetics.