DOPAMINE IN SCHIZOPHRENIA A REVIEW AND RECONCEPTUALIZATION PDF

Dopamine in Schizophrenia: A Review and Reconceptualization. Kenneth. L. Davis, M.D., Ren#{}S. Kahn, M.D., Grant Ko, M.D., and Michael. Davidson. OBJECTIVE The initial hypothesis that schizophrenia is a manifestation of hyperdopaminergia has recently been faulted. However, several new findings suggest. review of dopaminergic systems and receptors, pharmacological, postmortem and M. (a) Dopamine in schizophrenia: a review and reconceptualization.

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Kahn and Grant N. Post-mortem studies have shown high dopamine and HVA concentrations in various subcortical wnd regions and greater than normal dopamine receptor densities in the brains of schizophrenic patients.

However, reiew new findings suggest that abnormal, although not necessarily excessive, dopamine activity is an important factor in schizophrenia. Alessandro Bertolino Epidemiologia e psichiatria sociale Evidence, particularly from intracellular recording studies in animals and plasma HVA measurements, suggests that neuroleptics act by reducing dopamine activity in mesolimbic dopamine neurons.

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Dopamine in schizophrenia: a review and reconceptualization.

Showing of extracted citations. Comment in Am J Psychiatry.

YangJeremy K. The authors discuss these findings and their implications. The authors discuss these findings and their implications. SeamansNatalia Gorelova Neuropsychopharmacology Kritzer Cerebral cortex From This Paper Topics from this paper.

METHOD All published studies regarding dopamine and schizophrenia and all studies on the role of dopamine in rfview were reviewed. Attention has focused on post-mortem studies, positron emission tomography, neuroleptic drug actions, plasma levels of the dopamine metabolite homovanillic acid HVAand cerebral blood flow.

All published studies regarding dopamine and schizophrenia and all studies on the role of dopamine in dopxmine were reviewed.

The authors hypothesize that schizophrenia is characterized by abnormally low prefrontal dopamine activity causing deficit symptoms leading to excessive dopamine activity in mesolimbic dopamine neurons causing positive symptoms. Recent animal and human studies suggest that prefrontal dopamine neurons inhibit subcortical dopamine activity. It would explain the concurrent presence of negative and positive symptoms.

Xnd of dopamine and pathology of prefrontal neurons: Brain Antipsychotic Agents Scientific Publication. Skip to search form Skip to main content. The initial hypothesis that schizophrenia is a manifestation of hyperdopaminergia has recently been faulted.

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This hypothesis is testable and has important implications for treatment of schizophrenia and schizophrenia spectrum disorders. Topics Discussed in This Paper.

Dopamine in schizophrenia: a review and reconceptualization.

This paper has highly influenced 28 other papers. A literature review Alan Boyd D. The possible co-occurrence of high and low dopamine activity in schizophrenia has implications for the conceptualization of dopamine’s role in schizophrenia.

Citations Publications citing this paper. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License.

However, several new findings suggest that abnormal, although not necessarily excessive, dopamine activity is an important factor in schizophrenia.

CeaserDeanna M.