ImmunoCAP® ISAC and Microtest for multiplex allergen testing in people with difficult to manage allergic disease: a systematic review and cost analysis. A combination of innovative biochip technology with cutting edge research in molecular allergology has resulted in ImmunoCAP® ISAC – the most advanced in. The immuno-solid phase allergen chip (ISAC) test (Thermo Fisher ImmunoCAP ISAC) is a microarray assay system designed to assay specific.

Author: Akigis Kelkree
Country: Liechtenstein
Language: English (Spanish)
Genre: History
Published (Last): 7 April 2004
Pages: 382
PDF File Size: 17.71 Mb
ePub File Size: 11.2 Mb
ISBN: 609-6-49777-869-6
Downloads: 5907
Price: Free* [*Free Regsitration Required]
Uploader: Moogudal

ImmunoCAP ISAC Multiplexing – Phadia – Setting the Standard –

This tool has been designed to focus on elements of study design that we considered relevant to this specific study type, and is based upon the structure of the QUADAS-2 tool. Site built and designed by Design. Analyses to compare the effect of replacing single IgE with multiplex testing were difficult to perform because of lack of information regarding where the multiplex test would sit in the care pathway.

We did not identify any studies that reported clinical outcomes i. None of these studies reported test accuracy data. Please review our privacy policy.

See Appendix 1 for all search strategies. To assess the effects on clinical outcomes e. Seven studies investigated changes to treatment or management outcomes.

Candidate search terms were identified from target references, browsing database thesauri e. OFC testing was used as the reference standard. Study quality Studies of changes to management, treatment or diagnosis Seven studies investigated changes to treatment or management outcomes. As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history. However, when ISAC was used to measure the same component as single IgE testing or to measure multiple components homologous proteinswith a positive immunoap defined as any component positive, it appeared that equivalent sensitivities could be achieved without corresponding loss of specificity.


First Name Last Name. All potentially relevant studies cited in documents supplied by the test manufacturers had already been identified by bibliographic database searches. The inclusion criteria were expanded to allow studies that reported direct comparisons of diagnostic accuracy between single IgE testing and multiplex allergen testing, using SPTs or allergen challenge tests as the reference standard. Skin prick testing was used as the reference standard. Based on the searches and inclusion screening described above see Search strategy and Inclusion and exclusion criteriaabove20 publications, 30 — 49 of 15 studies, were included in the review; the results section of this report cites studies immunlcap the primary publication and, where this is different, the publication in which the referenced data were reported.

No studies of this type were identified.

ImmunoCAP Isacc — When you need the bigger jsac in allergy Trying to find the original cause for allergic reactions can sometimes feel like looking for a needle in a haystack. Two studies 3738 assessed the views of clinicians on whether or not ImmunoCAP ISAC testing provided information useful in the management of patients. Please try again later. The results of studies providing comparative accuracy data are also illustrated in receiver operating characteristic ROC space plots.

Results for raw egg were similar to those for boiled egg.

ImmunoCAP ISAC – When you need the bigger picture in allergy

If you are reporting a problem, please indicate what you were trying to do when the problem occurred, what you expected to happen, and what actually happened: Additional specimen collection, transport, or test submission information.

There was an error submitting your feedback. Certain tests have specimen requirements that differ for specimens shipped from New York state. Phadia AB, Uppsala, Sweden.

Change to management, that is, change to treatment or treatment plan e. The results were very variable between tests. In general, single IgE performed similarly to SPT both measured whole extractswhereas ISAC gave much more variable results for the three different components measured.


Chapter 3 Assessment of clinical effectiveness.

ImmunoCAP® ISAC at QML Pathology

Cut-off values were reported separately for each test and OFC testing was used as the reference standard. Studies that were conducted in non-UK settings and which assessed allergens considered unlikely to be relevant to UK populations e. The principal investigators of completed trials identified through searches of clinical trials registries that appeared to meet our inclusion criteria but for which no publication could be identified were contacted and asked to provide publication details or unpublished data.

The systematic review component of this assessment found no data on the clinical consequences of adding multiplex allergen testing to current clinical practice; therefore, a long-term economic model to inform health policy decision-making was not possible. Remind me later Don’t remind me again. Randomised controlled trials RCTscontrolled clinical trials, other comparative studies e. Search strategies were developed specifically for each database. The overall aim of this project was to summarise the evidence available to inform estimates of the clinical effectiveness and cost-effectiveness of adding multiplex allergen testing to the investigation of people with difficult to manage allergic disease, in secondary or tertiary UK care settings.

These will be reviewed by one of our allergy consultants in conjunction with your questionnaire, then sent to both you and to your GP if you opted for this in the questionnaire.

In general, individual ISAC components tended to have high specificity, but low sensitivity, relative to whole-allergen single IgE tests or SPT for the prediction of isax response. Support Center Support Center.